ANGel | Design Projects

Summary

Immune Innovation For Active Healing

ANGel is an engineered immune-activating hydrogel that accelerates healing by promoting rapid blood vessel regrowth.

Delayed tissue regeneration causes high failure chance for skin grafts:

160K Skin Grafts

Performed annually in the US treating burns and chronic wounds.

1 in 4 Fail

Procedures fail on average—leaving wounds open to chronic complications.

$32B Burden

Annual economic burden in the US from failed graft procedures.

Angiogenesis & Why It's Delayed

Angiogenesis is the process of new blood vessel formation, promoted by anti-inflammatory M2 macrophage signaling. Chronic inflammation prevents pro-inflammatory M1 macrophages to effectively differentiate into their pro-regenerative M2 state. When angiogenesis is prolonged, the risk of infection increases and likelihood of healing is decreases.

Various products are used for skin graft prep, but they fall short in:

High Cost

Up to $10,000 per unit for active wound healing dressing.

Long Wait Times

Frequent re-application and slow vascularization.

Passive Healing

Covers the wound but doesn't activate repair biology.

Poor Vascularization

Delays patient from getting skin grafting done.

Technical Approach/Methodology

ANGel promotes angiogenesis by working with your body's own immune system.

Macrophages are the equivalent of your body's custodian. They consume anything that they think is foreign, dead, or dangerous. When our hydrogel is applied to a wound, macrophages will "eat" this foriegn material, in which dead neutrophil factors are embedded in as well. When this happens, it promotes macrophages to send anti-inflammatory signals that will signal other macrophages and other immune cells who are already in an inflammatory state to become pro-angiogenic. Thus ANGel can accelerate the healing process for physcians and patients alike.

PEG-NHS ReagentPLL + AN Factors Reagent

Once ejected out, reagent will mix and hydrogel will solidify in 5–10 seconds.

Seamlessly integrates with physicians' workflows, in 4 steps.

Debridement & Sterilization
Eject ANGel onto wound & wait until it solidifies
Cover with any non-adherent dressing
Seal with film dressing

ANGel helps support the wound bed like a scaffold.

Outcomes

Out of 6 competitors, ANGel is the most cost efficient

Key Features:

Inexpensive

Infrequent application

Active immune healing

Rapid blood vessel growth

Antimicrobial

$10 billion market by 2030.
ANGel is ready.

The wound care market is oversaturated with overpriced, passive products. ANGel enters as a clinically superior, dramatically more affordable alternative.

Reimbursable

Revenue structured through HCPCS / CPT billing codes — mirroring established competitors like Apligraf.

Workflow-Ready

Fits the existing workflow that surgeons, nurses, and physician assistants already use. No new training.

Margin to Scale

Manufacturing at $260 vs. competitors at $10,000 creates strong margin — priced well below market rate.