Motion-Stabilized Blood-Flow Imaging Device
Project Description:
The use of in-vivo blood flow monitoring systems is essential for the clinical diagnosis of an assortment of cardiovascular related diseases1. The ever increasing population of elderly patients plays a major role towards the growth of the global blood flow measurement devices market with a CAGR of 9.10%2. Currently, laser speckle imaging (LSI) is a widely used noninvasive wide-field optical modality that enables superficial blood flow quantification3. However, many LSI devices require the use of various large components potentially limiting the widespread clinical utility. The need for a LSI system that does not compromise data quality while providing portability is crucial for use in clinical diagnosis.
The aim of this project is to develop a motion-stabilized flow imaging device developed under the guidance of Dr. Choi that can account for critical sources of motion-related errors that currently render robust handheld use of an imaging device an impossibility. Design requirements include: portability, ease-of-use, adequate data acquisition, and various requirements associated with design for manufacturing / design for assembly (DFMA). Design will be focused on functionality, usability, and quality of acquired data for analysis. Validation of device functionality will be performed upon analysis of data. Final product design should contain all electrical components in a elegant and aesthetically pleasing manner.
Project Mentor:
Engineering Mentor: Bernard Choi, PhD, Department of Biomedical Engineering, UCI, choib@uci.edu
Physician Mentor: None
Other Resources:
[1] Tang, Xuejun, et al. “Portable Laser Speckle Perfusion Imaging System Based on Digital Signal Processor.” Review of Scientific Instruments, vol. 81, no. 12, 2010, p. 125110., doi:10.1063/1.3505118.
[2] “Blood Flow Measurement Devices Market - Global Industry Size, Trends, Analysis and Segment Forecast 2018-26.” Inkwood Research, www.inkwoodresearch.com/reports/global-blood-flow-measurement-devices-ma....
[3] Lertsakdadet, Ben, et al. “Correcting for Motion Artifact in Handheld Laser Speckle Images.” Journal of Biomedical Optics, vol. 23, no. 03, 2018, p. 1., doi:10.1117/1.jbo.23.3.036006.
Team Members:
Adrian Williamson Bahani, Steven Yone-Shun Chang, Emil Martin Lundqvist, Natasha Sunil Palamuttam, Stephanie Miguel Pascua