Beating Heart Model

Project Description:
As technology and clinical experience advance, the medical devices to treat structural heart disease are becoming more complex and less invasive. There is a huge need for a more physiological in vitro cardiovascular test model to be able to effectively test and refine these devices.

The aim of this project is to develop a pulsatile cardiovascular system that mimics many of the major physiological properties (systolic and diastolic cardiac function, vessel/chamber compliance and resistance).

The project has three phases:
Phase 1: Cardiovascular system circuit with the following design constraints: Easy to set up (Plug and Play), Portable, Pulsatile and steady state, Echo and Flouro compatible
Phase 2: Measurement system that is able to measure: Cardiac Output, Mitral and tricuspid regurgitation, Pressures (LA. LV, RA, RV)
Phase 3: Synthetic Heart with different disease models (optional goal)

Project Mentor:
Engineering Mentor: Nima Nia, PhD, Principal R&D Engineering, Edwards Life Sciences, Nima_Nia@edwards.com
Physician Mentor: Yongen Chang, MD, PhD, Department of Nephrology and Hypertension, UCI, cyongen@uci.edu

Other Resources:
Note: students will need to sign an IP agreement to work on this project.

Rifat Omit Amin, Danielle Marie Becker, Blake William Echt, Amrith Anthony Karunaratne, Armando Alonso Munante, Audrey Renee Munoz